Active Ingredients: Ciprofloxacin
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Asia due to the growing prevalence of antibiotic resistance to the class of antibiotics in that region.
The incidence of side effects for ciprofloxacin is acceptable and relatively safe. No dose adjustments are generally required for mild to moderate renal impairment.
Even more remarkable, it seems to be a case where the first drug discovered of this class remains the 'gold standard' in terms of efficacy, with the other drugs developed by other pharmaceutical companies relegated to 'me-too' status and forced to compete on the basis of lower cost.
Encouraged by the magnitude of this success, as well as the influx of cash, Bayer Pharmaceutical embarked on a plan to remake itself from a minor pharmaceutical manufacturer into a major player in the international pharmaceutical business, with a lock on the antibiotic field.
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With an in vitro pharmacokinetic model IVPM, oral doses of 200 mg of trovafloxacin, 400 mg of ofloxacin, and 750 mg of ciprofloxacin were simulated and time-kill pharmacodynamic interactions were evaluated over 36 h.
Eight clinical isolates of S. Antibiotic preparations.
Trovafloxacin powder was supplied by Pfizer Inc. Ofloxacin powder was supplied by R.
Trovafloxacin and ofloxacin powders were dissolved in 0.